A Review on Targets and Synthesis Methods of Pyridine Compounds for Anti-Convulsant, Anti-Depressant Actions

Background: The market is overstocked with commercially accessible medications that contain pyridine rings, including abiraterone acetate and crizotinib for cancer, delavirdine for HIV/AIDS, isoniazid and ethionamide for TB, ciclopirox for anthelmintic conditions, and tacrine for Alzheimer's disease. These developments have raised hopes for how pyridine may help treat conditions relating to the central nervous system and caused research into the drug to continue growing. Objectives: The objective is to compile and analyze information on various pyridine-based derivatives that target various receptors and ion channels to provide relief from CNS disorders. Materials and Methods: To offer a comprehensive overview of the authorized medications and bioactivity data for compounds containing pyridine, research and review papers from PubMed and Google Scholar are integrated with data from other sources. Results: The majority of the responses covered in this article have directly provided readers with an understanding of various CNS receptors that pyridine analogs may target, in addition to synthetic methods for creating novel analogs that can be used to create new derivatives with more potent anticonvulsant and antidepressant properties. Conclusion: The majority of the responses covered in this article have directly provided readers with an understanding of various CNS receptors that pyridine analogs may target, in addition to synthetic methods for creating novel analogs that can be used to create new derivatives with more potent anticonvulsant and antidepressant properties.

Keywords:

Pyridine , anti-convulsant , Anti-depressant , CNS action , N-heterocycles