Sara Nikpour - Clinical Research Development Unit of Akbar Hospital, Pediatric Endocrinology & Metabolism, Department of Pediatrics, School of Medicine, Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Nasrin Moazzen - Assistant Professor of Pediatric Allergy and Immunology, Department of Pediatrics, School of Medicine, Allergy Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Tahereh Sadeghi - Clinical Research Development Unit of Akbar Hospital, Pediatric Endocrinology & Metabolism, Department of Pediatrics, School of Medicine, Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Background: Type ۱ diabetes mellitus manifests as a chronic autoimmune condition typically diagnosed in early childhood. Probiotics have been demonstrated in studies to stick to mucosal surfaces, block pathogenic bacterial attachment, release substances that improve barrier integrity, and control immune cell function. Concerning the importance of assessing the probable health benefits of probiotics on inflammatory markers, we aimed to review the effect of probiotics on inflammatory markers in patients with type ۱ diabetes mellitus.Methods: In this narrative review, we conducted a thorough search and retrieval of relevant English publications from databases including Web of Science, PubMed, Scopus, and Google Scholar. We utilized keywords such as "Type ۱ diabetes mellitus," "Probiotics," "Inflammatory Markers," "Cytokines," "Interleukins," "C-reactive protein," and "Tumor Necrosis Factor-alpha".Results: Lately, there has been a growing interest in employing probiotics to reduce biomarkers linked with inflammation and oxidative stress. The significance of probiotics in inflammation management is reviewed, with evidence indicating that their use may be associated with reduced inflammatory responses.Conclusions: Although previous studies have indicated positive impacts of probiotics on inflammatory markers among those with type ۱ diabetes mellitus, a more comprehensive investigation is essential to understand the potential mechanisms and clinical significance of their use.

Diabetes Mellitus, Probiotics, Inflammation