Mohammad Hossein Ghofrani - Assistant Professor of Exercise Physiology, Department of Exercise physiology, Department of Physical Education and Sport Sciences Karaj Branch, Islamic Azad University, Karaj, Iran.
Mojtaba Eizadi - Assistant professor of Exercise Physiology, Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran.

Introduction: Genetic and metabolic dysfunctions are primary contributors to the onset and intensity of type ۲ diabetes (T۲D) through the promotion of insulin resistance. The objective of this research was to examine the impact of high-intensity interval training (HIIT) on the expression levels of PPARγ and GLUT۴ in the subcutaneous adipose tissue, as well as its influence on insulin sensitivity among obese rats. Methods: Obesity induced by high fat diet (HDF) in ۱۴ male wistar rats and then were divided accidentally into exercise (HIIT, n = ۷) or control (n = ۷) groups. The rats or exercise group were completed an ۸ weeks HIIT (۵ days / weekly) and control rats remained no-training. Fasting blood glucose, insulin sensitivity and PPARγ and GLUT۴ gene expression in subcutaneous adipose tissue measured at ۴۸ hours after lasting exercise session. Independent T test used to compare each variables between ۲ groups. Results: HIIT resulted in significant decrease in fasting blood glucose (P = ۰.۰۰۱) and increase in insulin sensitivity (P = ۰.۰۰۱), PPARγ expression (P = ۰.۰۳۸) and GLUT۴ expression (P = ۰.۰۱۹) in subcutaneous adipose tissue compared with control rats. Conclusion: HIIT can be improving insulin sensitivity in obese rats. This improvement may be attributed to increase PPARγ and GLUT۴ expression in subcutaneous adipose tissue.

Gene expression, Glucose, High Intensity Interval Training, Obesity, Insulin sensitivity