Virgilio GALVIS
Alejandro TELLO
M. Margarita PARRA
Jesus MERAYO-LLOVES
Jaime LARREA
Carlos JULIAN RODRIGUEZ
Paul ANTHONY CAMACHO

Abstract Atropine has been used for more than a century to arrest myopia progression. Compelling evidence of its protective effect has been reported in well-designed clinical studies, mainly performed during the last two decades. However, its exact mechanism of action has not been determined. Experimental findings have shown that the mechanism is not related to accommodation, as was thought for decades. A review of the published literature revealed a significant amount of evidence supporting its safety and efficacy at a concentration of ۱.۰%, and at lower concentrations (as low as ۰.۰۱%).