Shahla Kakoei - ‎Associate Professor, Department of Oral Medicine, School of Dentistry, Kerman University of ‎Medical Sciences, Kerman, Iran
Bahareh Hosseini - ‎Assistant Professor, Department of Oral Medicine, School of Dentistry, Kerman University of ‎Medical Sciences, Kerman, Iran
Ali Akbar Haghdoost - ‎Professor, Department of Epidemiology, ‎School of Public Health, Kerman University of Medical Sciences, Kerman, Iran
Mojgan Sanjari - ‎Associate Professor, Department of Endocrinology, Physiology Research Center, Institute of ‎Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Maryam Alsadat Hashemipour - ‎Assistant Professor, Department of Oral Medicine, School of Dentistry, Kerman University of ‎Medical Sciences, Kerman, Iran
Ahmad Gholamhosseinian - ‎Professor, Department of Biochemistry, School of Medicine, Kerman University of Medical ‎Sciences, Kerman, Iran

OBJECTIVE: Oral manifestations in diabetic patients can have different causes. Possibly, one of these causes is salivary glucose. The aim of this study was to evaluate salivary glucose concentrations in patients with Type II diabetes mellitus (DM) and their association with oral and dental manifestations and compare them with normal adults. MATERIALS AND METHODS: In this analytical study, ۱۲۸ patients with Type II DM and ۱۳۲ non-diabetic healthy individuals were selected. The subjects’ blood and unstimulated salivary samples were collected. Salivary glucose concentrations were measured by glucose oxidase method. Then, the oral cavity and teeth were examined for oral manifestations such as ulcers, white and red plaques, lichenoid reaction, candidiasis and decayed missing filled teeth (DMFT) and periodontal disease index (PDI) indices. Data were analyzed by independent t-test and Pearson’s correlation test. RESULTS: The results of the present study showed that, in general, individuals with higher concentrations of salivary glucose had significantly higher DMFT and PDI, irrespective of belonging to the diabetic or the control group (P < ۰.۰۵۰). However, there was no significant correlation between salivary glucose concentrations and oral manifestations. Meanwhile, there was a significant correlation between salivary glucose concentration and glycated hemoglobin in diabetic patients compared with the control group (P < ۰.۰۰۱). CONCLUSION: The present study showed that the salivary glucose concentration had a positive association with DMFT and PDI in diabetic and non-diabetic patients. In this study, we found an association between salivary and blood glucose in diabetic patients.

Diabetes Mellitus, Decayed Missing Filled Teeth, Oral Manifestation, Periodontal Disease Index, Salivary Glucose