Alma Katasheva - Almaty Technological University, Department “Food Biotechnology,” Tole bi ۱۰۰ St., Almaty, Kazakhstan
Askar Kalekeshov - Kazakh National Women’s Teacher Tranıng University, Gogolya ۱۱۲/۱, Almaty, Kazakhstan
Meruyert Parmanbekova - Kazakh National Women’s Teacher Tranıng University, Gogolya ۱۱۲/۱, Almaty, Kazakhstan
Galiya Tatarinova - Kazakh-Russian Medical University, Department of Anatomy with Physiology Courses, Torekulova St., ۱۳, Almaty, Kazakhstan
Laura Koibasova - Institute of Genetics and Physiology, Al-Farabi St., ۹۳, Almaty, Kazakhstan
Zhadyra Nauryzbayeva - Kazakh National Women’s Teacher Tranıng University, Gogolya ۱۱۲/۱, Almaty, Kazakhstan
Zaida Rakhimova - Kazakh National Women’s Teacher Tranıng University, Gogolya ۱۱۲/۱, Almaty, Kazakhstan
Almagul Almabekova - Department of Chemistry, Kazakh National Medical University named afterS.D. Asfendiyarov, Almaty, Kazakhstan
Kuanysh Syman - Department of Biology, Faculty of Natural Sciences and Geography, Kazakh National Pedagogical University, Almaty, Kazakhstan

Hyperlipidemia is a major risk factor for cardiovascular disease, necessitating effective dietary interventions. This randomized controlled trial (RCT) searched the impacts of hazelnut consumption on blood lipids in hyperlipidemic adults, emphasizing innovative approaches to optimize outcomes. Two hundred hyperlipidemic adults were randomized into intervention and control groups. The intervention group received tailored hazelnut doses based on body weight for ۱۲ weeks, while the control group maintained their usual diet. Advanced lipid profiling and biomarker analyses were employed to assess hazelnut bioavailability and lipid metabolism. Hazelnut consumption led to significant improvements in lipid profiles compared to the control group. Participants receiving higher hazelnut doses demonstrated greater reductions in total cholesterol (p < ۰.۰۵) and LDL cholesterol (p < ۰.۰۱), with sustained effects observed during a ۱۲-week follow-up. Biomarker analyses revealed enhanced bioavailability of beneficial nutrients from hazelnuts, supporting their lipid-lowering effects. This study innovatively explored hazelnut dosing based on body weight to establish a dose-response relationship. Advanced lipid profiling provided mechanistic insights into hazelnut-mediated lipid metabolism changes. Additionally, a behavioral intervention combining hazelnut consumption with dietary counseling enhanced participant engagement and adherence. Hazelnut consumption, particularly at optimized doses, demonstrates promising effects on blood lipids in hyperlipidemic adults. Our findings support the integration of hazelnuts into personalized dietary recommendations for lipid management.

Biomarker analyses, Hazelnut consumption, Hyperlipidemia, Lipid profiles, Randomized controlled trial