Majid Rezaei-tavirani
Mostafa Rezaei Tavirani
Mona Zamanian Azodi
Mohammadreza Razzaghi
Hamideh Moravvej Farshi

Abstract Introduction: Application of laser in medicine and cosmetic purposes has raised grossly in recent years. There are contradictory finding about its side effects. In this research critical differentially expressed proteins after irradiation erbium:yttrium–aluminum–garnet (Er:YAG) laser on skin are investigated.Methods: Proteome data including ۳۱ proteins were obtained from a proteomics investigation of laser irradiation, Er:YAG on female mouse skin that are published by Pan et al. The query proteins and ۱۰۰ related ones were included in the protein-protein interaction (PPI) network. The central nodes were determined and all of nodes were included in action maps. Expression, activation, inhibition, binding, and reaction were considered in action plan.Results: Numbers of ۱۶ proteins were recognized by STRING database and were included in the network. Except PHRF۱, the other ۱۵ query proteins were included in the main connected component of the constructed network. Ten central nodes of the network and ten numbers of top query proteins based on degree value were identified as central proteins of the network. All nodes of the network analyzed via action maps and the important acted nodes were determined as RPSA, GAPDH, TPT۱, DCTN۲, HSPB۱, and PDIA۳.Conclusion: Two balanced processes including cancer promotion and cancer prevention were after irradiation were identified. Keywords: Laser irradiation Erbium yttrium–aluminum–garnet (Er YAG) Skin Care Proteomics Protein-protein interaction network analysis Biological process