Raheleh Faramarzi Garmroudi - Assistant Professor of Neonatal-Perinatal Medicine, Department of Pediatrics, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences
Feisal Rahimpour - Pediatric Cardiologist, Fellow in Interventional Electrophysiology, Rajaie Cardiovascular Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
Maryam Aghdasi - Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Emadzadeh - Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Hassan Mottaghi Moghaddam shahri - Associate Professor of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam Moradian - Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Reza Saeidi - Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
elahe Heidari - Department of pediatrics, Faculty of Medicine, Mashhad university of medical sciences, Mashhad, Iran

Background: Perinatal asphyxia may cause multiple organ dysfunctions, including myocardial dysfunction. This study aimed to evaluate the prevalence and features of myocardial dysfunction in perinatal asphyxia. Methods: This study was carried out on ۳۱ neonates (≥۳۷ weeks) with perinatal asphyxia who were admitted to the Neonatal Intensive Care Unit (NICU). The neonates underwent Electrocardiography (ECG) and Echocardiography (ECHO) in the first ۷۲ hours of birth. Moreover, in the first ۲۴ hours of birth, ۱ cc of blood was taken from the patients for cardiac troponin I (cTnI) and creatine kinase-myocardial band (CK-MB) testing. Following that, venous blood gas was recorded one hour later. Results: The mean ۱- and ۵-min Apgar scores were ۴±۱.۷۶ and ۶.۸±۱.۶, respectively. The mean value of serum cTnI was ۴±۱.۷۶, and mean level of CK-MB was obtained at ۱۳۶.۵۱±۲۵۸.۵۱. ECGs were of grade ۱. Mitral valve E-wave/Early diastolic (۵۱%), followed by Tricuspid Regurgitation Vena Contracta (۴۸.۴%) was found to be the commonest ECHO abnormality, and Mitral annular plane systolic excursion (۹۶.۸%) was the most normal ECHO parameter. Infants with ECG grade ۱ changes had a lower ۵-min Apgar score (P=۰.۰۱۴), and higher serum cTnI level (P=۰.۰۰۲). ECG changes were not significantly correlated with the mean of Apgar at ۱ min, umbilical vein PH, and CK-MB. Conclusion: ECG and ECHO changes, serum troponin I level, and ۵-min Apgar score were found to be the predictors for myocardial dysfunction caused by asphyxia in newborn infants

Myocardial changes, Birth Asphyxia, echocardiography, Electrocardiography, neonate