Synthesis and Identification of Some New Imidazolidine-۴-one, Oxazolidine-۴-one and Thiazolidine-۴-one Derivatives from Phenidone and Their Antimicrobial and Antioxidant Activities Investigation
Publish place: Advanced Journal of Chemistry-Section A، Vol: 7، Issue: 6
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
View: 50
This Paper With 16 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_AJCS-7-6_015
تاریخ نمایه سازی: 30 مرداد 1403
Abstract:
The reaction of ۱-phenyl-۳-pyrazolidone (phenidone) bound to sodium hydride and reacting with chloroacetyl chloride give compound (۱) which then reacts with hydrazine hydrate to give compound (۲). Compound ۲ when reacted with substituted benzaldehydes, produced five derivatives of Schiff's base (۳-۷) these derivatives were then introduced into the cyclization process with glycine, ۲-chloro acetic acid and ۲-mercaptoacetic acid to yield new imidazolidine-۴-one, oxazolidine-۴-one and thiazolidine-۴-one containing ۱-pheny-۳-pyrazolidone. The newly synthesized compounds were structurally validated using FTIR, ۱HNMR, and ۱۳CNMR spectroscopy in vitro studies were conducted to assess the antimicrobial properties and total antioxidant capacity, as well as the reducing power assay for the compounds. The results shown [۸, ۹ and ۱۴] have good antioxidant activity
Keywords:
Authors
Hussein Qabel
Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
Suaad M.H. Al-Majidi
Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
