Assessment of Immunohistochemical Expression of Cyclin D۱ and E-Cadherin in Laryngeal Squamous Cell Carcinoma

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JMCH-7-8_001

تاریخ نمایه سازی: 15 شهریور 1403

Abstract:

Laryngeal cancer, particularly the squamous cell carcinoma subtype, is prevalent all over the world and is characterized by a poor prognosis and high mortality rates. Currently, no definitive prognostic markers exist for predicting the behavior of the tumor. The aim of this study is to examine the correlation between cyclin D۱ and E-cadherin expression with some clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC). ۶۰ cases of LSCC were retrospectively studied concerning the clinicopathological features and the potential prognostic role of cyclin D۱ and E-cadherin expression in laryngeal carcinoma, using immunohistochemical staining scores on paraffin-embedded cancer tissues from patients who were treated with surgical excision. Reduced E-cadherin expression was significantly correlated with tumor grade (p = ۰.۰۲۸۸), T stage (p = ۰.۰۴۱), and lymph node metastasis (p = ۰.۰۰۳). Regarding Cyclin D۱, a statistically significant correlation was found with lymph node metastasis (p=۰.۰۱۹). In contrast, cyclin D۱ expression was not significantly correlated with TNM stage or tumor grade (p=۰.۹۹ and ۰.۶۶, respectively). Evaluating expression of cyclin D۱ in conjunction with E-cadherin expression in laryngeal squamous cell carcinoma may prove beneficial in identifying patients with lymph node metastasis. Tumor grade, stage, and nodal metastasis can significantly affect E-cadherin expression in patients with LSCC. However, further studies using genetic testing are recommended to assess the role of E-cadherin in tumor progression.

Keywords:

Cyclin D۱ , E-cadherin , laryngeal squamous cell carcinoma , Larynx , Squamous Cell Carcinoma

Authors

Amany I.A. Abo-Saif

Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Abdulkarim Hasan

Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Rania R. Abdel-Maqsoud

Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Amira N. Ismail

Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Hebatullah A.Z.E. Abdelazim

Otorhinolaryngology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Nabila E.A. Elneklawy

Otorhinolaryngology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Tawfik A. Elkholy

Otorhinolaryngology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Shimaa S. Abu-Seadah

Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Samah M. Attia

Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Marwa A. Elkholy

Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Asmaa A.M. Moussa

Pathology Department, Nasr City Cancer Center, Cairo, Egypt

Noura A.A. Ebrahim

Oncologic Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt

Rajab A. Alzahrani

Otorhinolaryngology Division, Surgery Department, College of Medicine, Al-Baha University, Al-Baha, Saudi Arabia

Ahmed Abdulwahab Bawahab

Pathology Department, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia

Diaa Ashmawy

Pathology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt

Moustafa Ali M. Ibrahim

Otorhinolaryngology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Mahmoud M. Elbahrawy

Otorhinolaryngology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

Marwa M. El-Mosely

Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

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