The Protective Effect of Ethanolic Extract of Olive Leaf on Aluminum Phosphide-Induced Cardiac Toxicity in Rats

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JNFS-9-3_008

تاریخ نمایه سازی: 17 شهریور 1403

Abstract:

The purpose of this study is to evaluate a treatment for aluminum phosphide (ALP) poisoning, which is known as “rice tablet”. Methods: In the present study, the impact of different doses of ethanolic extract of olive leaves (۱۰۰, ۲۰۰, and ۴۰۰ mg/kg) on ALP (۱۲۰ mg/kg)-induced cardiotoxicity was evaluated in anesthetized-gastrotomized adult male Wistar rats. Thirty-five rats were randomly assigned into five groups (n=۷) as follows: control (AC) and treatment groups [ALP+Olea۱۰۰ (AO۱۰۰), ALP+Olea ۲۰۰ (AO۲۰۰), and ALP+Olea ۴۰۰ (AO۴۰۰)]. Physiological data including blood pressure, heart rate, electrocardiogram (ECG), as well as oxidative stress markers were measured in heart tissues. Results: ALP-intoxication led to perturbed normal ECG and increased oxidative stress. Administration of olive leaf extract at various concentrations, however, mitigated bradycardia after ۹۰ minutes, following ALP-intoxication (in AO۲۰۰), hypotension (in AO۱۰۰), and cardiac conduction disturbances (decreased QTC in the AO۲۰۰ ۳۰ (P<۰.۰۵), ۶۰ (P<۰.۰۰۱), and ۹۰ (P<۰.۰۵) minutes after intoxication)   and decreased PR ۶۰ (P<۰.۰۵) and ۹۰ minutes (P<۰.۰۱) after intoxication. This was compared with baseline as well as detrimental changes in cardiac electrophysiology [mitigated ST-segment elevation  in AO۲۰۰  and depressed T-wave in the AO۲۰۰ (P<۰.۰۵) and  AO۴۰۰ (P<۰.۰۱)  groups ۹۰ minutes after intoxication] Conclusion: Based on these authentic results, it seems that olive leaf extracts can be useful in reducing the severity of symptoms in ALP-poisoned individuals and could be utilized in a poisoning emergency.

Authors

Maryam Moazami

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Mehrnoosh Sedighi

Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran

Marzieh Rashidipour

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran

Sara Haydari

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Ghafar Ali Mahmoudi

Department of Internal Medicine, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Saber Ghaderpour

Department of Physiology, Tabriz Faculty of Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran

Morteza Bakhshesh

Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran

Afshin Nazari

Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran

Maryam Moghimian

Department of Physiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

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