Emergence of Multidrug-Resistant and Extensively Drug-Resistant Non-Fermenting Gram-Negative Bacilli in a Tertiary Hospital in India

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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JR_JOMMID-12-2_004

تاریخ نمایه سازی: 4 مهر 1403

Abstract:

Introduction: Non-fermenting Gram-negative bacilli (NFGNB), particularly the Acinetobacter baumannii complex (ABC) and Pseudomonas aeruginosa, are common causes of infections in both hospitalized patients and outpatients, posing significant clinical and therapeutic challenges. The primary objective of this study was to conduct a comprehensive analysis of NFGNB, specifically ABC and P. aeruginosa, isolated from pus specimens obtained from both hospitalized patients and outpatients. Methods: This study investigated the antibiotic resistance patterns of NFGNB, focusing on ABC and P. aeruginosa, isolated from pus samples collected from both hospitalized patients and outpatients. The isolates were tested for multidrug resistance (MDR) and extensive drug resistance (XDR) using standardized microbiological protocols. The data were analyzed using descriptive statistics to summarize the findings. Results: Out of ۱۲۳۴ pus samples received, ۱۱۷ (۹.۵%) NFGNB were isolated, accounting for ۳۰% of the total Gram-negative bacilli (GNB) isolates. The majority of NFGNB (۸۲.۹%, n = ۹۷/۱۱۷) were isolated from inpatients, with surgical site infections being the most common clinical condition (۳۳.۳%, n = ۳۹/۱۱۷). Among the NFGNB isolates, P. aeruginosa was the predominant species (۷۶.۹%, n = ۹۰/۱۱۷), followed by A. baumannii (۲۲.۲%, n = ۲۶/۱۱۷). Antimicrobial susceptibility testing revealed that ۳۷.۷% (n = ۳۴/۹۰) of P. aeruginosa isolates were MDR and ۱۳% (n = ۱۲/۹۰) were XDR, while ۶۵% (n = ۱۷/۲۶) of A. baumannii isolates were MDR and ۲۶.۹% (n = ۷/۲۶) were XDR. Conclusion: This study highlights the emergence of NFGNB as significant nosocomial pathogens, exhibiting a high degree of resistance to commonly used antibiotics. The findings underscore the urgent need to enhance and strictly implement effective antibiotic stewardship policies, including the development of new antibiotic regimens and antimicrobial resistance surveillance programs, to combat the growing resistance of nosocomial pathogens and ultimately improve patient outcomes.

Keywords:

Acinetobacter baumannii , Multidrug-resistant (MDR) , Extensive drug resistant (XDR) , Non-fermenting Gram-negative bacteria (NFGNB) , Pseudomonas aeruginosa

Authors

Rinku Yadav

Department of Microbiology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India. Pin Code: ۱۲۴۰۰۱

Sonia Mehta

Department of Microbiology, B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. Pin Code: ۱۶۰۰۵۵

Rosy Bala

Department of Microbiology, M.M Institute of Medical Sciences & Research, Mullana, Haryana, India. Pin Code: ۱۳۳۲۰۷

Varsha Ashok kumar Singh

Department of Microbiology, Rajmata Vijaya Raje Scindia Government Medical College, Bhilwara, Rajasthan, India. Pin Code: ۳۱۱۰۰۱

Muskan Khullar

Department of Microbiology, District Hospital, Mohali, Punjab, India, Pin code: ۱۶۰۰۵۵

Parminder Singh

Government Civil Hospital, Kaithal, Haryana, India. Pin Code: ۱۳۶۰۲۷

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  • Sharma D, Vyas N, Sinha P, Mathur A. Non fermentative ...
  • Mohan N, Gnanasekar D, Tk S, Ignatious A. Prevalence and ...
  • Al-Zaidi JR. Antibiotic susceptibility patterns of Pseudomonas aeruginosa isolated from ...
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  • Maniyan G, Vedachalam D, Chinnusamy N. Characterization and antimicrobial susceptibility ...
  • Sambyal S, Sharma P Shrivastava D. Anti-biofilm Activity of Selected ...
  • Kaur A, Gupta V, Chhina D. Prevalence of metalo-β-lactamase-producing (MBL) ...
  • Kakati B, Nupur K, Sonika A, Garima M. Multidrug resistant ...
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  • Sodhi K, Mittal V, Arya M, Kumar M, Phillips A, ...
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