The application of bioactive biopolymer scaffolds in regenerative medicine

The combination of different types of polymers has been used to engineer tissue scaffolds using polymers, ceramics, and their composites. In the field of biomimicry, three-dimensional (۳D) scaffold designs have been employed for tissue regeneration due to their favorable physicochemical properties and biological activity. Scaffolds fabricated through salt leaching, particle sintering, hydrogels, and lithography have been successful in enhancing cell growth under laboratory conditions and tissue regeneration under in vivo conditions. Protective systems derived from the decellularization of organs or tissues have become popular due to their biocompatibility and assured biological activity. Traditional scaffold fabrication techniques often struggled to create complex structures with higher resolution, a lack of repeatability, and the involvement of multiple stages. However, ۳D printing technology has overcome several limitations of traditional techniques and facilitated the use of multiple thermoplastics and hydrogels for scaffold fabrication and microstructure engineering, making drug delivery easier.

Keywords:

biopolymer , hydrogel , regenerative medicine , scaffold