Canine Toxic Epidermal Necrosis (TEN) in a ۱۴-Year-OldFemale Shih Tzu-Terrier Dog

Canine toxic epidermal necrosis (TEN) is a rare and life-threatening cutaneous drugreaction that is described as full-thickness necrosis of the epidermis with mild dermalinflammation. A ۱۴-year-old female Shih Tzu-Terrier was referred to our clinic with acute andextensive erythema, vesicles, and ulcerations, especially on the ventral skin, perineum, andclaws. The dog had also exhibited lethargy and had been administered oral Co-trimoxazole andanti-fungal drugs ۳-۱۴ days before the development of the skin lesions. Histopathology ofbiopsies from the skin lesions revealed Basal and squamous cells in epithelium underwentnecrosis with many prominent pyknotic and karyorrhectic nuclei. Necrosis of the epidermis ismore suggestive of canine toxic epidermal necrosis (TEN). Hematological analysis showeddifferences in WBC count, mainly neutrophils . This report describes the successfulmanagement of a well-documented case of canine toxic epidermal necrosis (TEN) in Iran.

Keywords:

Canine , Pharmacodermia , Shih Tzu-Terrier , Toxic Epidermal Necrosis