Hamideh Gholami - Department of Oncology, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
Lida Garrosi - Department of Obstetrics and Gynecology, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
Shabnam Tofighi - Department of Obstetrics and Gynecology, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
Zahra Ghadimi - Department of Obstetrics and Gynecology, Zanjan University of Medical Sciences, Zanjan, Iran.

Background: Although an optimal screening model is still under investigation, pre-eclampsia is a leading cause of perinatal morbidity. The association between cancer-antigen-۱۲۵ (CA-۱۲۵) and pre-eclampsia has been discussed in several studies recently. Objective: We aimed to determine the association between CA-۱۲۵ and preeclampsia and estimated fetal weight. Materials and Methods: This case-control study was performed on ۳۰ pregnant women with pre-eclampsia who were homogenized in terms of age, body mass index, and gestational age with ۳۰ normal pregnant women. Participants were recruited via convenience sampling. The level of CA-۱۲۵ in blood at the time of termination of pregnancy was measured by Enzyme Linked Immunosorbent Assay. The urine sample was used to check proteinuria. Blood pressure and pregnancy outcomes were assessed and recorded. Results: The mean serum CA-۱۲۵ level in study group was considerably higher than control group (p < ۰.۰۰۱). Elevating the level of CA-۱۲۵ has increased the likelihood of pre-eclampsia by ۱.۵ times. A significant direct correlation was obtained between CA-۱۲۵ level and the amount of urinary protein (r = ۰.۶۰۵, p < ۰.۰۰۱). Also, significant but negative correlation was obtained between the CA-۱۲۵ level and the estimated weight of the fetus (r = -۰.۵۹۳, p < ۰.۰۰۱). Conclusion: Increasing the serum level of CA-۱۲۵ with high sensitivity and specificity is significantly associated with the occurrence of pre-eclampsia and estimated fetal weight.

CA-۱۲۵, Pre-eclampsia, Birth weight., CA-۱۲۵, پره اکلامپسی, وزن تولد.