Solvent-free, one-pot, four-component synthesis of ۲H indazolo[۲,۱-b]phthalazine-triones catalyzed by Isatin-So۳H coated on amino propyl modified magnetic nanoparticles (MnFe۲O۴@APTES@isatin-SO۳H) as a recyclable magnetic nanoparticle

The study involved the application of isatin-SO۳H coated on aminopropyl-modified magnetic nanoparticles (MnFe۲O۴@APTES@isatin-SO۳H) as a reusable nanocatalyst for the synthesis of ۲H-indazolo[۲,۱-b] phthalazine triones. The comprehensive characterization techniques employed, including FT-IR, SEM, TEM, XRD, confirm the structural and functional integrity of the nanocatalyst. It exhibited excellent performance in a one-pot, four-component synthesis under solvent-free conditions at ۸۰ ºC. The method offered advantages such as short reaction time, high yields, and straightforward purification. Additionally, the magnetic properties of the nanoparticles allow for straightforward recovery using an external magnet, enabling multiple reuse cycles without significant loss in catalytic performance. This feature is crucial for sustainable practices in chemical synthesis, making the MnFe۲O۴@APTES@isatin-SO۳H nanocatalyst a promising candidate for future applications in organic synthesis.

Keywords:

“aminopropyl , magnetic nanocatalyst , one-pot , four-component , solvent-free conditions