A GREEN EFFICIENT SYNTHESIS OF SOME PYRAZOLOPYRIDINE DERIVATIVES IN WATER

A simple, facile, efficient and three component procedure for the synthesis of 4-aryl-pyrazolo[3,4- b]pyridine-5-carbonitrile by the reaction of 3-(1-methyl-1H-pyrrol-2-yl)-3-oxoproanenitrile, 5-amino-3-methyl-1H-pyrazole and aldehyde in Water under ultrasonic irradiation is reported this rapid methodproduced the products in short reaction times(4- 5min) and excellent yields (87-97%).

Keywords:

3(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile , 5- amino-3-methyl-1H-pyrazole , pyrazolopyridines , multicomponent , ultrasound irradiation , Water