Association of ۵՛-Untranslated Region Polymorphism of VEGF Gene with Henoch-Schönlein in North West of Iran

Background: Henoch-Schönlein purpura (HSP) is an lgA mediated small vessel systemic vasculitis disease in children. The etiology and pathogenesis of HSP disease remain unknown. However, environmental and genetic risk factors could play important roles in susceptibility to HSP disease. In this study we investigated the association of ۵՛-untranslated region polymorphism (-۶۳۴G/C) of VEGF gene with HSP among Iranian Azeri Turkish population. Methods: Thirty unrelated Iranian Azeri Turkish children with HSP and fifty healthy unrelated subjects without HSP and other inflammatory diseases were enrolled in this population. -۶۳۴G/C polymorphism of VEGF gene was genotyped by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) technique. Results: The distribution of CC genotype in VEGF -۶۳۴G/C polymorphism statistically showed a significant difference in HSP patients in compare to that of control group (P= ۰.۰۰۹). Conclusions: The CC genotype of VEGF -۶۳۴G/C polymorphism could be associated with susceptibility to HSP disease in Iranian Azeri Turkish ethnic group.

Keywords:

-۶۳۴G/C polymorphism , vascular endothelial growth factor (VEGF) , Henoch-Schönlein purpura (HSP) , Iran