Investigation of the Effects of High-Fat and Normal Diets on Cholesterol Biosynthesis in the Liver

Nowadays, cardiovascular diseases are considered one of the most significant causes of mortality worldwide. These diseases, including issues such as heart attacks, heart failure, and coronary artery diseases, claim the lives of millions of people globally each year. One of the most important reasons for the onset of these diseases is the presence of high levels of cholesterol in the blood. Cholesterol is a natural fatty substance that plays very important roles in the body. It acts as one of the essential components of the cell membrane, helping to maintain the structure and stability of cells. Additionally, cholesterol is involved in the production of essential hormones such as sex hormones and steroid hormones. However, increased blood cholesterol levels, particularly low-density lipoprotein cholesterol (LDL), can lead to fat deposition in the artery walls and eventually to heart diseases. LDL cholesterol, known as 'bad' cholesterol, can attach to the artery walls if its levels in the blood are elevated and create fatty plaques. These plaques gradually cause the narrowing of the arteries and reduced blood flow, which can lead to cardiovascular diseases such as heart attacks and strokes. Therefore, controlling blood cholesterol levels is of special importance. In this study, the effects of high-fat and normal diets on cholesterol biosynthesis in the liver of two generations of C۵۷BL/۶J mice will be examined to gain a better understanding of the genetic and environmental impacts.

Keywords:

High-fat diet , Normal diet , Cholesterol biosynthesis