Novel approaches and limitations in viral gene therapy of cancer diseases

Gene therapy is a medical technique that involves modifying or manipulating a person's genes to treat or prevent disease. It aims to introduce new or modified genes to correct the defective genes responsible for the development of the disease or to help fight the disease. Giving nucleic acid to cells as viral gene therapy to replace cells and repair or prevent diseases, especially cancer, has demonstrated potential therapeutic properties with related obstacles. This therapeutic strategy has attracted attention to its ability to treat conditions with some or no effective treatments. As one of the main obstacles in the application of viral vectors, it is not cost-effective to produce these vectors on a large scale. In this review, viral gene therapy has been discussed against various cancer diseases by some recent progresses and challenges, especially Adenovirus, Adeno-Associated Virus (AAV), retroviral, lentiviral, and HSV vectors.

Keywords:

Cancers , Gene Therapy , Viral gene therapy , Adeno-Associated Virus