Design of synthetic method and optimization of condition for synthesis of ethyl-[2-(4- methoxyphenyl)-1-methylethyl]-amine as an intermediate of mebeverine.

This study includes designing and optimization of a synthetic method to prepare the ethyl [ 2-(4-methoxy phenyl)-1-methyl ethyl]-Amin compound as the raw material in the synthesis of mebeverine. This compound is formed in a direct Reductive aminatione reaction from the reaction of 4-methoxy phenyl acetone and ethyl Amin under the condition of Isopropanol solvent and Sodium cyanotrihydridobora Catalyst in the room temperature .

Keywords:

ethyl -[2-(4-methoxy-phenyl)-1-methyl-ethyl]–amin , 4-methoxy phenyl acetone , Reductive amination , Sodium cyanoborohydride (NaBH3CN)