Interaction of iron (III) DiAmsar with HSA and BSA by UV–vis spectroscopy

UV–vis measurement is applicable to explore the structural change and to know the complex formation.Iron (III) diamine-sarcophagine (DiAmsar) has attracted great attention in biological and medical applications. Inparticular, for any potential in vivo application, the interaction of iron (III) DiAmsar with serum albumins is crucial. As a step toward the elucidation of the fate of iron (III) DiAmsar introduced to organism, at first, iron (III) DiAmsar wassynthesized and then its interactions with human serum albumin (HSA) and bovine serum albumin (BSA) were systematically investigated by UV–vis spectroscopy. The knowledge of the interaction and binding of iron (III) DiAmsar to HSA and BSA may open new avenues for future application of this kind of compounds in pharmacology

Keywords:

Iron (III) DiAmsar , HSA , BSA , UV–vis spectroscopy