DIHYDROPYRIMIDIN-2(1H)-ONES CATALYZED BY NASA

A new and efficient synthesis of dihydropyrimidinone drivatives from the three-component condensation reaction of urea, ethylacetoacetate and aromatic aldehydes using nano alumina sulfouric acid (NASA) as solid acid catalyst. The features of this procedure are mild reaction conditions, good to excellent yields, short reaction times and operational simplicity.

Keywords:

Solvent free , Urea , Ethylacetoacetat , Nano alumina sulfouric acid