Survival of Children with Germ Cell Tumors in Ali Asghar Hospital since 1990 to 2003

Publish Year: 1386
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJP-2-1_003

تاریخ نمایه سازی: 5 آبان 1393

Abstract:

Background and Objective: Germ cell tumor (GCT) accounts for approximately 2-3% of all malignancies in children. In this respect, about 20% of patients with GCT are still resistant totherapy. Materials and Methods: The cross-sectional strategy of this survey was undertaken on 57 patients with germ cell tumor who admitted to Ali Asghar Children hospital during the years 1990- 2003. In this study, information regarding sex, age, pathological findings, clinical signs, treatment,and survival (event-free survival) were gathered in order to have better treatment and follow-up.The obtained data were analyzed using SPSS software.Results: The findings showed that the mean age of patients was 4.9 ± 0.1 years (1 months-14years). Meanwhile, 54% and 46% of patients were male and female respectively with a ratio of 1.1. Regarding site of involvement, 57.8% and 42% of patients had sacrococcygeal and gonadaltumors respectively. In addition, regarding their pathological typing, 61.4%, 12.2%, 14%, and10.5% of them had yolk sac tumor, dysgerminoma, malignant teratoma, and embryonal carcinoma respectively. The most common clinical signs were buttock mass, testicular mass, an abdominalmass, and abdominal pain in 31.5%, 28%, 17.5%, and 10.5% of patients respectively. All of thepatients were treated with chemotherapy (bleomycin, vinblastin, cisplat). Mean duration of followup was 48.4 months. In this regard, 31.5% of the patients were alive, no information was availablefor 15.7% of them, and 52.6% of cases were expired. Meanwhile, 70% of the patients had tumorrelapse. In this regard, event-free survival (EFS) for patients was 42%. Conclusion: The analysis of the treated patients showed that extragonadal location of primarytumor (especially sacrococcygeal), level of AFP above 10 ng/ml in patients, an age equal to or greater than 6 months, and metastatic disease were the most unfavorable factors for overall survival .

Authors

Shahla Ansari

Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran

Parvaneh Vossogh

Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran

Ali Tabarok

Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran