Histological Changes in Gastric Biopsies from Helicobacter Pylori- Infected Patients With and Without Peptic Ulcer

Background and Objective: Long period risk of gastric carcinoma in people affected with chronic Helicobacter pylori gastritis is 5 times more than normal people. Perhaps histological changes dueto helicobacter pylori infection could be used for screening people at risk of gastric carcinoma andpeptic ulcer. Materials and Methods: This study has been carried out as a cross-sectional process and we compared histological changes observed in Helicobacter pylori chronic gastritis in 30 patients withpeptic ulcer and 30 patients without the ulcer and then classified them according to Sydney scoringsystem, and after collecting data, we analyzed them by SPSS software. Results: Sixty percent of patients with ulcer were male and forty percent were female. In addition,56.7% of patients without ulcer were male and 43/3% were female without a statistically significantdifference (p = 0.793). Mean age in ulcer group was 56.4 years and in non-ulcer group was 48.9 years that there was no significant statistical difference (p = 0.057). Chronic gastritis frequencyincreases within people in their sixth decade and after that. There was no significant difference fordegree of infection with Helicobacter pylori (p = 0.346), metaplasia (p =0.885), chronicity (p = 0.796) and degree of activity (p = 0.249), atrophy (p = 0.781) in patients with or without ulcer.Conclusion: There was no significant difference in any of the variables of the study includingdegree of infection with Helicobacter pylori, chronicity, disease activity and intestinal metaplasia between both groups with and without peptic ulcer.

Keywords:

Helicobacter pylori , Peptic ulcer , Gastric cancer