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Title

The Diagnostic Value of Serum IgG-Antigliadin, IgA Anti-endomysial and IgA Anti-tissue Transglutaminase Antibodies for Pediatric Celiac Disease

Year: 1387
COI: JR_IJP-3-4_008
Language: EnglishView: 513
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Authors

Mitra Mehrazma - Dept. of Pathology, Iran University of Medical Sciences, Tehran, Iran.
Alireza Abdollahi - Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran.
Elham Talachian - Dept. of Pediatrics, Iran University of Medical Sciences, Tehran, Iran.

Abstract:

Background and Objective: Celiac disease is an autoimmune disorder, characterized by inflammation, villous atrophy, and crypt hyperplasia of the small bowel mucosa. In this studywe considered and compared sensitivity and specificity of serological tests in patients with celiac disease.Materials and Methods: In this cross-sectional study we prospectively recruited children with suspected celiac disease. An intestinal biopsy specimen was obtained from all patients. Celiac diseasediagnosed on the basis of histologic findings of Marsh classification. A serum sample was taken atthe time of biopsy for serologic tests. Findings were analyzed using SPSS program, t-test, and chisquare tests.Results: Out of a total of 134 children in this study, seventy (52.21%) patients were boy and sixty four (47.8%) patients were girl. Celiac disease was diagnosed in 14 (10.4%) of the patients.In serologic tests, 11 patients (78.6%) were positive for antigliadin-Ab, 4 (28.6%) for anti tissuetransglutaminase Ab, and 9 (64.3%) for antiendomysial antibody. Sensitivity of antigliadin-Ab was 78.6% and its specificity was 95.9%. Sensitivity of anti tissue-transglutaminase Ab was 28% and itsspecificity was 95%. Sensitivity of antiendomysial Ab was 64% and its specificity was 96%. Conclusion: Positive serologic tests are supportive of the diagnosis in those with characteristic histopathologic changes on small intestinal biopsy. The best tests for this purpose are the IgAantiendomysial antibody or IgA anti tissue-transglutaminase, both of which are highly sensitive and specific.

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Mehrazma, Mitra and Abdollahi, Alireza and Talachian, Elham,1387,The Diagnostic Value of Serum IgG-Antigliadin, IgA Anti-endomysial and IgA Anti-tissue Transglutaminase Antibodies for Pediatric Celiac Disease,https://civilica.com/doc/302632

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Type of center: علوم پزشکی
Paper count: 4,659
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