Mahmood Khaniki - Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran.
Zeynab Nazary - Dept. of Gynecology, Mazandaran University of Medical Sciences, Mazandaran, Iran
Kazem Zendehdel - Dept. of Epidemiology, Karolinska University, Stockholm, Sweden
Fereshte Fakur - Dept. of Gynecology, Gilan University of Medical Sciences, Rasht, Iran.

Background and Objective: The aim of this study was to compare the screening performance of a new modified liquid-based cytology method (Liquiprep™) with conventional PAP smear (CP) ina low risk population, using colposcopy followed by histology as gold standard . Patients and Methods: This cross-sectional study was performed on random referred specimens to a general gynecological clinic in Tehran, during 20 months by a split-sample method. In bothCP and Liquiprep™ group, all positive and 10% of negative results of smears were followed by colposcopy. A biopsy was taken whenever any atypical transformation zone seen. Sensitivity,specificity, negative and positive predictive values (PV), and overall accuracy of both methods wereanalyzed in relation to histology. Results: A total of 1265 patients were analyzed by two methods. In 158 (12.5%) of cases histologicaldiagnosis was made. Liquiprep™ samples (94.7%) were more adequate than CP (92.1%). There was not any low or high-grade squamous intraepithelial lesion (SIL). Atypical squamous cell of undetermined significance (ASC-US) was diagnosed more with CP than with Liquiprep™ (1.43%vs. 0.79%) while pathologically 60% of ASC-US in Liquiprep™ and 16.6% in CP had degrees of SIL. The Liquiprep™ had a significantly higher sensitivity (83% vs. 66%) and positive PV (83% vs. 33%) than the CP to detect SIL at histology but the difference in specificity was non significant(98% vs. 86%). Conclusions: This study confirms the superiority of the Liquiprep™ method to detect cervical lesions in a low risk population.

Cervix Uteri, Cytology, Cervical Pap Smear, Liquiprep, Screening