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Significance of Hepatitis B Core Antibody as the Only Marker of Hepatitis B Virus Infection in High Risk Patients

Year: 1388
COI: JR_IJP-4-2_005
Language: EnglishView: 465
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Amitis Ramezani - Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
Minoo Mohraz - Iranian Research Center for HIV/AIDS, Tehran, Iran.
Mohammad Banifazl - Iranian Society for Support Patients with Infectious Diseases, Tehran, Iran
Ali Eslamifar - Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran


Background and Objective: Presence of hepatitis B core antibody (anti-HBc) in the absence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) is defined, asisolated anti-HBc. little is known about the clinical significance of the isolated anti-HBc in hepatitisB virus (HBV) infections. The aim of this study was to assess the significance of anti-HBc as the onlymarker of HBV infection in high risk patients.Patients and Methods: In this cross-sectional study, 395 patients including 289 patients onchronic hemodialysis (HD) and 106 HIV infected subjects were enrolled. HBsAg, anti-HBs, anti-HBc, Hepatitis C antibody (anti-HCV) and Alanine aminotransferase (ALT) levels were tested in allsubjects. The presence of HBV-DNA was determined quantitatively in plasma samples of patients with isolated anti-HBc by real-time PCR. Results: Of 395 patients, 40 (10.13%, 95% CI, 7.1%-13.1%) had isolated anti-HBc. HBV-DNA was detectable in 12 of 40 patients (30%, 95% CI, 15.8%-44.2%) who had isolated anti-HBc.Conclusion: Our study showed that detection of isolated anti-HBc could reflect unrecognized HBV infection; hence, screening of these patients is useful to preventing of HBV transmission.


Hepatitis B Core Antigens , Hepatitis B Antibodies , Immunologic Marker , Iran

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Ramezani, Amitis and Mohraz, Minoo and Banifazl, Mohammad and Eslamifar, Ali,1388,Significance of Hepatitis B Core Antibody as the Only Marker of Hepatitis B Virus Infection in High Risk Patients,

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