Effect of Plantago major L. extract on PTZ- induced seizure threshold in NMRI male mice

Epilepsy is a common neurological disorder after stroke. Despite various anticonvulsants current research to discover new drugs with better efficacy and fewer side effects, continue. Herbs with natural variety of materials with different properties,this research are appropriate for field .the present study Plantago major( P.major) extract is a powerful antioxidant. In the present study the effect of plant extract of Plantago on seizures induced by PTZ injection in male NMRI mouse.Methods: the experiment used 50 NMRI mouse (eight in each group)as follows:the control ,control sham,control plus (50 , 25, 10,5 mg / kg).The mouses in each group received injection60 mg/kg of PTZ(60mg/kg body ieght,interperitoneally,n=10 in each group) a single injection.The animals experimental were injected with(50 , 25, 10,5mg / kg) P.major extract interperitoneally just 30 min before each PTZ injection.the animals group of control and sham rececied saline instead of P.major extract.after treatment,The behavirs animals were recorded for 20 min.. Data were expressed as mean ± standard deviation. In order to compare the groups, analysis of variance (ANOVA) was used. P < 0.05 values were considered to be statistically significant.Results: The results of repeated injection of P.major extract (50,25,10 mg / kg) than the control groups in the seizure threshold compared to the control group, there was a significant increased (p <0/05).so,treatment groups (50,25,10 mg/kg) in phases 1 compared to the control group, there was a significant reduction (p <0/05 ) .Conclusions: These results are probably due to the effect of ethanol on Plantago is a GABAergic system

Keywords:

Pentylentetrazole , Seizure , hydroalcoholic extract plantago major L , Mice