Alterations of triglyceride and cholesterol in response togel extract in HepG2 cells and hyperlipidemic guinea pigsAloe vera

Aloe veraA.veraA. veraA. veraA. veraA. veraA. veraA. verais well-known for its pharmacological and nutritionalproperties. The aim of the present study was to determine the effect ofgel extracts on the secretion and cell content of triglyceride (TG) andcholesterol (TC) in HepG2 cells and their short-term effects on the dietaryhyperlipidemic guinea pig model. The effects of increasingconcentrations of crude gel and its alcoholic and hydro-extractwere compared to HepG2 cells in both basal and TG induced conditionswith 20 mM glucose for 24 h. In addition, 24 male guinea pigs wererandomly separated into six experimental groups as follows: control,hyperlipidemic control, levostatin control and receiving groups(fed with lipid-rich diet supplemented with crude gel, alcoholic orhydro-extracts of gel). Treatments were carried out for 10 d TGand TC levels were measured in both collected fluid (sera and media) andextracted tissue (HepG2 and liver). Although basal and stimulatedconditions of crude gel and its hydro-extract decreased the secretion andcell content of TG, compared to the control (p<0.05). This pattern was notseen with the alcoholic extract. Furthermore, did not have anyeffect on the serum or liver contents of TG or TC. Our results suggest thatcould be a beneficial supplement to modulate the levels of TG andTC. However, it does not appear to be a short-term lipid modulator forhyperlipidemia.

Keywords:

Aloe vera , triglyceride cholesterol , HepG2 cell , guinea pig