Histomorphometrical evaluation of the gastrointestinal mucosafollowing chronic administration of Ghrelin in rat
Publish place: Iranian Journal of Veterinary Medicine، Vol: 5، Issue: 3
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVM-5-3_007
تاریخ نمایه سازی: 26 اردیبهشت 1394
Abstract:
Ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (GH)-releasing effect in the pituitary. It alsoincreases appetite and feeding behavior. Recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immunefunction, and suggest a role for ghrelin in bone physiology. In this study, the effect of chronically administered ghrelin on the histomorphometricalproperties of stomach and different parts of intestinal mucosa were evaluated in a rat model. Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P<0.05). Chronic administration of ghrelin could therefore exert a gastrointestinal protective effect, as it promotes mucosal growth in the proximal gut and enhances gastric glands in oxyntic mucosa
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Authors
S.M Banan Khojasteh
of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
M Taati
Department of Pathobiology, Faculty Department of Pathobiology, Faculty
A Kheradmand
Department of Pathobiology, Faculty Department of Pathobiology, Faculty
F. Sheikhzadeh
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran