Immunohistochemical evaluation of lymphocyte types infiltrateinto the canine seminomas
Publish place: Iranian Journal of Veterinary Medicine، Vol: 6، Issue: 1
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVM-6-1_006
تاریخ نمایه سازی: 26 اردیبهشت 1394
Abstract:
BACKGROUNDS: Seminoma is frequently observed in human and canine testes especially in cryptorchids. Canine and human seminomas are typically associated with leukocytic infiltration. OBJECTIVES:We aimed to identify the type of lymphocytes that infiltrate to seminomas. METHODS: Tumor infiltrating lymphocytes were evaluated by immunohistological techniques in 5 dogs with diffuse seminoma. Routine pathological examination of these specimens showed diffuse seminoma with tumor infiltrating lymphocytes in all cases. RESULTS: Lymphocytes in seminomas were predominantly T cytotoxic (CD3+, CD8+) cells. These cells were distributed diffusely, but patchy around the vessels. B-cells were also identified as some rare single cells diffusely scattered in the tumoral parenchyma.CONCLUSIONS:The results of this study showed that the lymphocyte infiltrating cells are mainly T lymphocytes particularly CD8 cytotoxic type.
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Authors
S Hesaraki
Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran