One-pot and one-step novel N-methylation of 2,6-Diaminopyridine

2,6-Diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to over-alkylations, we earn a mixture of amino products. Consequently, they aren't selective in the case of secondary amines preparation. Also, the synthesis of secondary amines is a problematic field in organic chemistry. In this research, 2,6-diaminopyridine N-methylatedselictivity was done from reaction with sodium azide and orthoformic ester in low time with good yields.

Keywords:

2 , 6-Diaminopyridine , N-methylation , one-pot reaction , one-step reaction