A green synthesis of novel schiff bases derivated from 4-Amino-5-phenoxymethyl-2,4- dihydro-[1,2,4]triazole-3-thione

Despite the remarkable progress in diagnostic and antifungal drugs research in past 10years ,still complexity of the characteristics of patients continue to make the managementof fungal infection is a great challenge [1]. 1,2,4-triazole compounds not only offer aninteresting chemistry but also their various derivatives possesses diverse chemotherapeuticactivity. The recent literatures are enriched with the progressive finding about the synthesisand biological activity of 1,2,4-triazole heterocyclic compounds. 4 amino -1,2,4-triazole -3-thiol are known to exhibit diverse pharmacological profile including analgesic antiinflammatory,anti allergic, anti viral, anti–hiv, anti microbial, anticonvulsant, antidepressant ,antifungal, anti cancerous ,anti bacterial and anti tubercular activities [2]. In thiswork, first, compound 1,2,4-triazole was produced by reaction of hydrazine hydrate andcarbon disulphide and then reaction with phenoxy acetic acid. Imine triazoles wereproduced by reaction of this compound with benzaldehyde and it's derivatives. Thestructures of all the synthesized compounds were confirmed by IR, 1H-NMR , 13C-NMRand MASS spectra.