Three-component synthesis of 1H-pyrazolo[1,2-]phthalazine-5,10-dione carbonitrile and carboxylate in the presence of Fe3O4@SiO2 Core-Shell nanoparticles as green, efficientand robust catalyst

Multicomponent have been paid much attention by synthetic organic chemists worldwide due tothe effectiveness of multiple component reactions at building functionalized, drug-likesstructures from different families of compounds in a single step and thus we believe thatdiscovering and developing new and novel ones is an important pursuit in academic chemistry[1].Among a large diversity of heterocyclic compounds, bridgehead hydrazine heterocycles haveattracted considerable attention because they show some pharmacological properties andbiological activities [2].Nanoparticles have received increasing attention as an alternative support for catalysis. As thediameter of the particle decreases to the nanometer scale, ample external surface area becomesavailable for surface modifications. Fe3O4 nanoparticles have been extensively studied due totheir unique magnetic properties and potential applications. However, the chemical stability ofFe3O4 is pretty poor and usually a protection layer such as SiO2 is required to ensure theirchemical stability and improve their dispersing ability. Owing to its special advantage over othermaterials, silica has been considered as one of the most ideal layers for protection of themagnetic Fe3O4 nanoparticles [3].In according to the above mentioned points related to important growth of nanotechnology andMCRs in the synthesis of heterocyclic compounds herein we wish to report an efficient, greenmethod for the synthesis of 1H-pyrazolo[1,2-]phthalazine-5,10-dionederivatives fromphthalhydrazide, aldehydes, and malononitrile or ethyl cyanoacetate in the presence ofFe3O4@SiO2 core-Shell nanoparticles in excellent yields and short reaction times.