Comparison of Serum Autoantibodies to Desmogleins I, III in Patients with Oral Lichen Planus and Healthy Controls
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 10، Issue: 2
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-10-2_001
تاریخ نمایه سازی: 13 مرداد 1394
Abstract:
Background & Objective: Lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesionbut its etiology is not completely understood. Desmogleins I and III are the main desmosomal transmembrane proteins. These proteins have been identified as the autoantigen of the autoimmune disease. The aim of this study was evaluation of serum autoantibodies against desmogleins ?, ??? in oral lichen planus. Methods: We attempted to determine the etiology of this disease with evaluation of these serum factors. Thirty-five patients with oral lichen planus and 35 healthy controls were recruited and tested for serum autoantibodies against desmogleins ?, ??? and indirect immunofluorescence also performed. Data were analyzed by statistical–analytical methods (Independent sample t-test) with using the SPSS.15 software.Results: Serum autoantibody against desmoglein ? had no significant difference in the two groups (P=0.31) but significant increase in serum autoantibody to desmoglein ??? was found in patients with oral lichen planus (P=0.00). Conclusion: It seems that autoantibody against desmoglein III has a significant role in the pathogenesis of oral lichen planus.
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Authors
Narges Gholizadeh
Dept. of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
Hossein Khoini Poorfar
Dept. of Pediatric Hematology and Oncology, Hamadan University of Medical Science, Hamadan, Iran
Ali Taghavi Zenouz
Dept. of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
Masoumeh Vatandoost
Dept. of Pediatric Dentistry, Tabriz University of Medical Science, Tabriz, Iran