ISOCYANURATE-PMO: AN EFFICIENT NANOCATALYST FOR THE SYNTHESIS OF 4HPYRANS

An improved one-pot three-component and environmentally benign approach for the synthesis of a wide range of densely functionalized 2-amino-3-cyano-4H-pyran annulated derivatives has been described by the reaction of aryl aldehydes, malononitrile and diverse enolizable C-H activated acidic compounds in the presence of isocyanurate-PMO, as a periodic mesoporous organosilica, in water under reflux conditions. In comparison to the conventional methods, the significant advantages of this green protocol are high to quantitative yields, avoiding the use of any hazardous catalyst or solvent, shorter reaction times, low cost, and straightforward work-up procedure.

Keywords:

Periodic mesoporous organosilicas (PMOs) , multicomponent reactions (MCRs) , 2-amino-4H-chromene , Heterogeneous catalysis