Novel Three-Component Synthesis Of Pyrano[2,3-c]Pyrazole Derivatives Catalyzed by ZnO Nanoparticles

One of efficient and convenient procedures for the synthesis of ethyl-6-amino-4-aryl-3-methyl-1-phenyl-1,4- dihydropyrano[2,3-c]pyrazole-5-carboxylate derivatives based on three component reaction involving ethylcyanoacetate, pyrazolone and various aromatic aldehyde in the presence of ZnO nanoparticles as heterogeneous catalysts and using dry ethanol as a solvent. The ZnO nanoparticles exhibited excellent catalytic activity and the proposed methodology is capable of providing the desired products in good yield (90-95%) and short time reaction

Keywords:

pyrano[2 , 3-c]pyrazol , ethyl cyanoacetate , ZnO nanoparticles , heterogeneous catalysts