In-vitro Investigation of Poly (Urethane) and Poly (Urethane)/Nanohydroxyapatite Biocomposite to be Applied in Bone Tissue

(11 Bold): Nanohydroxyapatiye (nHA), due to well biocompatibility and similarity to the bone materials,was used in biocomposite synthesis. Biodegradable viscoelastic poly(ester urethane)-based scaffolds show great promisefor tissue engineering. In this study, the preparation of hydroxyapatite nanoparticles (nHA)/poly(ester urethane)composite scaffolds using a salt-leaching-phase inverse process is reported. Formation of physical bonds betweenPoly(Urethane)(PU) and nanohydroxyapatite was evaluated with Fourier transform infrared spectroscopy (Brocker) (FTIR).TG/DSC analysis was done on the products. In vitro cell growth study on PU and PU/nHA was done by osteoblastcells. FE-SEM and Alizarin images was used to understand cell growth better.

Keywords:

(11 Bold): Nanohydroxyapatite , poly (urethane) , scaffold , osteoblast cell , Bone tissueengineering