Noncovalently-functionalized C60 by hyperbranched polyglycerol as a new candidate for cancer therapy

An efficient synthesis and characterization of supramolecular systems including fullerene (C60) andhyperbranched polyglycerol with β-cyclodextrin core (HPG-g-CD) has been explained. Indeed, we introduce a simpleway to afford a water-soluble fullerene assembly through end-to-end intermolecular inclusion complexation of a β-cyclodextrin with a fullerene. In this system, the deprotonation of the β-cyclodextrin acted as a core for formation oflinear-hyperbranched supramolecular amphiphiles. Then, it was used as a macroinitiator in order to enable anionic ringopening polymerization of glycidol. Host-guest interactions between aromatic rings of fullerene and cyclodextrin cavityof β-CD-graft-PG in aqueous solution lead to the formation of supramolecules which are stable complexes in aqueoussolution. Equilibrium state was approached after seven days without the use of organic cosolvents. The 1:2 stoichiometryof the [C60@ (HPG-g-CD)2] complexes was demonstrated a stable phase in a soluble conditions. In contrast, native β-CDforms nanoparticles with C60. The particle sizes of the C60 were determined by dynamic light scattering.

Keywords:

Fullerenes , Hyperbranched polymers , Polyglycerol , Cyclodextrin