Novel nanoporous hydrogel for controlled release of tetracycline hydrochloride drug

A highly swelling nanoporous hydrogel was synthesized via UV-irradiation graft copolymerization ofacrylamide grafted onto kappa-carrageenan (PAAm-g- κC). The PAAm-g- κC hydrogel showed three-dimensionalnetworks with irregular nano porous structure with 250 nm size. Lastly, the potential of this hydrogel for tetracyclinehydrochloride (TH) release was examined. The results showed that 95% of TH was released in pH 8 after 4h at 37 °Cwhich were best fitted with Korsmeyer kinetic model.

Keywords:

Nanoporous hydrogel , Tetracycline hydrochloride , Carrageenan