INVESTIGATIGATE THE RELATIONSHIP BEWEEN SERUM LEVELS OF HOMOCYSTEINE ,OXIDATIVE STREES AND LIPID PROFILES IN WOMEN WITH PRE ECLAMPSIA

Pre-eclampsia is a syndrome which is characterized by the increase in blood pressure to above 091041, oedema and proteinuria, and is the second leading cause of maternal death in developing countries, including Iran. A total of 5 % of pregnant women are affected worldwide. Oxidative stress is one of the key factors involved in the development of pre-eclampsia. The present study aims to investigate the effect of the concentration of homocysteine, oxidative stress and lipid profiles on pre-eclampsia.This case-control study was conducted on healthy pregnant women visiting Taleghani and Al Zahra hospitals in Tabriz, Iran, as well as on women with pre-eclampsia admitted to these two hospitals. Fifty-eight samples were selected as controls and 5+ subjects were selected as cases. The blood samples were prepared with their consents. Parameters measured included lipid profiles (total cholesterol, triglyceride, LDL-c and HDL-c), MDA as a marker of lipid peroxidation, homocysteine concentration in blood, glutathione peroxidase (GPX) enzymes, superoxide dismutase (SOD) and the total antioxidant status (Canakci et al.). In addition, a questionnaire was completed to collect information on age, gestational stage, height, weight, weight before pregnancy and folic acid (B9) intake.The results obtained in this study are based on the inhibition of confounding variables and indicate significant differences in homocysteine status, total antioxidant status (Canakci et al.) and TG in both groups. However, there was no significant difference in the concentration of GPX-SOD enzymes, OSI index, and or total cholesterol, LDL-c and HDL-c.Increased homocysteine and TG could be considered as factors in the aetiology of pre-eclampsia. In addition, the dietary intake and serum antioxidant regime that are evaluated under TAS are important in the reduction of oxidative stress induced by homocysteine and improving the status of pre-eclampsia-affected women.

Keywords:

homocysteine , oxidative stress , lipid profiles , pre-eclampsia