synthesis of spirooxindoles with three component reaction between β-ketoesters, malononitrile andisatin derivatives in the presence of Alum.SiO2 nanoparticles as a new nano catalyst

In this reseaech, some of the spirooxindole derivaties were prepared via β-ketoesters, malonoitrile and isatin derivativesin the presence Alum.SiO2 NPs as an effective, recyclable and inexpensive catalyst. The products were identified byIR, 1HNMR, 13C NMR spectra, and melting point. The size of nanoparticles characterized by SEM and TEMtechniques. A novel multicomponent synthesis of a series of spirooxindol derivatives is described. The procedures wascarried out applying Alum/SiO2 supported on NPS as the novel catalyst giving rise to high to excellent yielded syntheticroute of spirooxindol compounds. The major advantages of this protocol are short reaction time ,good yields , simpleprocedure work up as well as friendly synthesis. In this work, some of the spirooxindole derivaties were prepared via β-ketoesters, malononitrile and isatin derivatives in the presence Alum.SiO2 NPs as an effective, recyclable andinexpensive catalyst. The products were identified by IR,1HNMR,13CNMR spectra, and melting point. The size ofnanoparticles characterized by SEM and TEM techniques.(scheme 1)

Keywords:

Spirooxindoles , Molononitrile , System.Alum.SiO2 , nanoparticles