p Mohagheghzadeh - M.Sc. Student in Organic Chemistry, Department of Chemistry, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
m.m Ghanbari - Assistant Professor of Organic Chemistry, Department of Chemistry, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

The present paper describes studies on the synthesis of the thiazine, and structurally related derivatives. First, we report a simple method for the preparation of thiohydantoin derivatives that can easily be scaled up in the laboratory. After that, a two-step reaction is described to synthesis and further analyzing the influence of hydrogen shift on the thiazine derivatives. The second step include a triplex reaction which lead to synthesis imidazo[2,1-b][1,3]thiazines in the presence of para toluene sulfonic acid as the catalyst. Moreover, resulting in a much more selective method than the previously reported procedures is the advantage of this method.

Hydrogen shift, Para toluene sulfonic acid, Thiohydantoin, Thiazine, Heterocycles