Health Positive Uses of Genetically Modified Food Crops as a Source of Biopharmaceuticals

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 26 اسفند 1394


Molecular farming, or bio-pharming, has recently received much of attention for production of valuable recombinant proteins, with a few already being marketed. The use of whole plants for synthesis of pharmaceutical proteins offers various advantages in economy, scalability and safety over conventional production systems. GM plants are suitable for the inexpensive production of large amounts of functional, recombinant macromolecules, such as blood substitutes, vaccines, anti-cancer antibodies, plasma proteins, enzymes, cytokines and growth factors, and the expressed proteins, rangingfrom the smallest antigen-binding domains, to full-length, and even multi-meric proteins, are almost comparable to their mammalian counterparts. Delivery of a biopharmaceutical product by direct ingestion of the modified food crops removes the need for purification. Such biopharmaceuticals and edible vaccines can be stored and distributed as seeds, tubers, or fruits, making immunization programs in developingcountries potentially cheaper and easier. It is anticipated that this technology has the potential to greatly benefit human health by making safe recombinant pharmaceuticalswidely available. Here, we discuss facts, recent developments and perspectives of this field in detail


Raheleh Khatibzadeh

Department of Horticulture, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran

Majid Azizi

Department of Horticulture, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran

Mokhtar Jalali Javaran

Department of Plant Breeding, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran