Maryam Mousavi - P.hD Student, Zanjan University of Medical Sciences,Zanjan, Iran& Department of pathology Amir – momenis Hospital
Seyed Reza Hosseini - Zanjan University of Medical Sciences,Zanjan,Iran
Davood Sohrabi - Assistant Professor, Department of Community Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Influenza H1N1 is very important worldwide and point mutations that occur in virus Gene is a threat for World Health Organization (WHO) and druggists, which make this virus be resistant A (H1N1) virus to previous Antibiotic. Influenza epidemics cause severe respiratory illness in 30 million to 50 million people and kill 250 thousand to 500 thousand people worldwide every year. Today drug design is not in trial and error way , because of cost and wasting time, bioinformatics studies is essential for drug design . In this paper, we studied binding site Neuraminidase( NA) enzyme, (that is very important in drug design) in 310K temperatures and different dielectrics, for the best drug design. Information of NA enzyme was extracted from data bank protein (PDB) and NCBI sites. The new sequences of N1 were downloaded from NCBI influenza virus sequence database. Drug binding sites were assimilated and homology modeling using Argus lab 4.0, HyperChem 6.0 and Chem. D3 soft wares. Their stability was assessed in different dielectrics and temperatures.

Neuraminidase enzyme – Influenza A (H1N1) – Binding site –Molecular Mechanic