Shohreh Alipour - Pharmacy Department, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran
Sahar Akbari - Pharmacy Department, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Ahmadi - Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

Ondansetron hydrochloride, a selective 5-HT3 receptor blocker, is an effective antiemetic drug with oral bioavailability of 60% and half-life of 4-5hours. The present study was carried out to preparefast dissolving films of ondansetron hydrochloride to increase patient compliance and improve efficacy of thisdrug. Films were prepared by solvent casting method, using poly vinyl alcohol, poly vinyl pyrrolidone and konjac glucomannan as film formers and PEG400 asplasticizer. Natural and synthetic sweeteners were used for masking bitterness of the drug. Satisfactory results were obtained from evaluation of physical characteristics of fast dissolving films of ondansetron hydrochloride including: thickness (0.37-0.39 mm), surfacepH (6.77), folding endurance (up to 300 times) and tensile strength (35.75-50.93 g/cm²). Films were also subjected to an in vitro dissolution and release studies.In vitro drug release studies indicated 93-95% release in 5 min. Fast dissolving films of ondansetron could be a potential alternative for the currently marketed oral formulation, parenteral form and suppository with better patient compliance and higher bioavailability for the rapid control of emesis.

Fast dissolving film, Konjac glucomannan, Ondansetron, Poly vinyl alcohol, Solvent casting