Synthesis and Biological Evaluation of Metronidazole Derivatives as Anti- Giardia Agents
Publish place: Trends in Pharmaceutical Sciences، Vol: 1، Issue: 2
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 17 فروردین 1395
Abstract:
Nitroimidazole derivatives such as Metronidazole (MTZ) have been used as anti- protozoa and anti-anaerobic bacteria. In this study several derivatives of MTZ were synthesized and evaluated against Giardia lamblia cyst. MTZ were reacted with several alkyl halide to obtain o-alkyl MTZ derivatives,then products were purified and their chemical structures were confirmed by spectral analysis (1HNMR and Mass). In order to assess biological evaluation, all compounds were investigated against 25 Giardia samples isolated from Giardia-infected patients. Results showed that compound 2 had the most activity on cyst of Giardia in comparison with MTZ.
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Authors
Bahador Shahriari
Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra Rezaei
Pharmaceutical Sciences Research Center, and Department of Medicinal Chemistry, School of Pharmacy Shiraz University of Medical Sciences, Shiraz, Iran
Soghra Khabnadideh
Pharmaceutical Sciences Research Center, and Department of Medicinal Chemistry, School of Pharmacy Shiraz University of Medical Sciences, Shiraz, Iran
Hossein Sadeghpour
Pharmaceutical Sciences Research Center, and Department of Medicinal Chemistry, School of Pharmacy Shiraz University of Medical Sciences, Shiraz, Iran