Theoretical Study of Using 2-Phenylthialcohols as Antidote Drugs. The Role of Stereochemistry.
عنوان مقاله: Theoretical Study of Using 2-Phenylthialcohols as Antidote Drugs. The Role of Stereochemistry.
شناسه ملی مقاله: NBCI04_067
منتشر شده در چهارمین همایش ملی بیوتکنولوژی ایران در سال 1384
شناسه ملی مقاله: NBCI04_067
منتشر شده در چهارمین همایش ملی بیوتکنولوژی ایران در سال 1384
مشخصات نویسندگان مقاله:
Ali Amoozadeh - Semnan University, Department of Chemistry.
Parivash Peyvandi - Red Crescent Society of Semnan
خلاصه مقاله:
Ali Amoozadeh - Semnan University, Department of Chemistry.
Parivash Peyvandi - Red Crescent Society of Semnan
There are some commercial antidote drugs like Dimercaprol, Succimer, or Penicilamine as parmaceutical chelators. They are bidental ligands which could give strong complexes with heavy metals as poisons. This paper introduces 2-Phenylthioalcohols as theoretically new antidote drugs and describes the role of stereochemistry on their effect. The stability of mentioned ligands and their complexes with are calculated by semi-empirical AM1 method and compared together and to ordinary used antidote drugs. Also the simple synthetic methods have introduced for their preparation. +2Zn
کلمات کلیدی: Antidote, Pharmaceutical chelators, Phenylthioalcohols, Semi-empirical AM1 method
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/45140/