Ali Ezabadi - Department of Chemistry, Faculty of Science, Tehran Central Branch, Islamic Azad University, Tehran, Iran
Majid Ghermez Cheshmeh

Multicomponent reactions (MCRs) are receiving increased attention because of their high synthesis efficiency, atom economy molecular diversity, as well as extensive applications in combinatorial chemistry and diversity-oriented synthesis. The Biginelli reaction, one of the most important and useful multicomponent reaction, offers an efficient way to get multifunctional 3, 4-dihydropyrimidin-2(1H)-ones (DHPMs) and related heterocyclic compounds. The great interest in DHPMs stems from the fact that this class of compounds and their derivatives has, in principle, pronounced biological activity. L-Cysteine Hydrochloride acts as an efficient, green and readily available catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones. This method, in comparison with the classical Biginelli reaction, has several advantages such as short reaction time, high yields, and easy work-up.

L-Cysteine hydrochloride, Biginelli reaction, solvent-free conditions